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Conclusion: Even a strong depolarization, which produces initial rates of insulin secretion beyond the extent produced by glucose stimulation, is virtually unable to elicit a secretory response when the ATP generation by oxidative phosphorylation is rapidly inhibited

When ROS levels exceed the antioxidant defenses, spermatozoa are subjected to oxidative stress, leading to detrimental molecular changes, including lipid peroxidation, DNA fragmentation, and protein oxidation

Ideally, patients who use this medication as a form of obesity management will accompany their weight loss with a significant lifestyle change and participate in a weight loss management program with their doctor or a nutritionist

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Patients should discuss eligibility and local availability with their GP , who can provide referral to specialist weight management services where appropriate

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