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Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes

doi: 10.1038/s41420-024-02278-8 244 ZhengYSunJLuoZLiYHuangY

However, combining them should only be done under medical supervision to monitor for side effects and effectiveness

doi: 10.3389/fevo.2018.00161 80

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These mechanisms are dose-dependent and exposure-dependent clinically significant at doses substantially above the standard 222 mg three times per week, or when daily dosing is sustained without breaks