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A recently solved structure of a heme-bound mPGES-2 allowed solving this discrepancy
Trends Pharmacol Sci 19:328334 Rao SD, Yin HZ, Weiss JH (2003) Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
Among those tested, Cur10 demonstrated the strongest binding, exhibiting the lowest IC 50 value of 9.64 M, while Cur07 and Cur06 showed IC 50 values of 19.86 M and 20.79 M, respectively (467)
As people age, they produce less glutathione
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