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HO-1 known as stress response protein is a 32-kDa heat shock protein that converts heme into carbon monoxide, iron, and bilirubin, and is expressed exclusively on the anti-inflammatory M2 macrophage under oxidative stress condition 18

Now, multiply that variance across dozens or hundreds of applications in a long-term study

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a 2025 IV pilot in two adults used 10 mg and 20 mg single infusions and reported no adverse effects (Lee et al., Alternative Therapies in Health and Medicine)