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Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD

In the UK, Graham Phillips describes himself as the pharmacist who gave up drugs and runs two pharmacies, in Letchworth and Broadstairs, that offer a prolongevity programme that promotes weight loss through natural means, such as cutting out ultra-processed foods and monitoring blood glucose levels

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Comparing two combination regimens (A and B), Regimen B, which employed a 28-day cycle with split-dose oral Vorinostat (days 17 and 1521) and dose-dense, lower-dose ixabepilone (days 2, 9, and 16), demonstrated superior clinical efficacy compared to Regimen A (21-day cycle)

doi: 10.1016/j.mrgentox.2016.09.010 121 HeydarzadehSKiaSK