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Biopsy of the dark brown intestinal mucosa showed that there were different degrees of macrophage deposition in the lamina propria interstitial cells of the mucosa, but the epithelial cell layer was normal (Figure 3)
At the same time, SURMOUNT-1 showed that more than 50% of participants achieved a body weight reduction of more than 20%, surpassing the outcomes of existing anti-obesity medications
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All this finding suggests that signaling mechanisms contributing to GLP-1/GLP-2R and GIPR action require further in-depth investigation
Nat Rev Immunol (2021) 21(9):54869
12 In addition, OBGYNs are seeing progressively more patients with obesity, and hence are increasingly seeing associated complications ( e.g ., infertility, high-risk pregnancies, and gynecological cancers)
