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It has been reported in mouse models of RA that the uptake of anthocyanins can bring down TNF- levels ( in vivo study on RA-induced DBA-1/J male mice reported downregulation of IL-1, IL-6, and TNF-, inhibited NF- signaling, and activated extracellular signal regulated kinase 1/2 (ERK1/2) ( Kaempferol, an important phytochemical found in grapefruits, can bring down the level of inflammatory cytokine IL-1, inhibiting the cell signaling pathways like phosphorylation of ERK1/2, p38, and JNK and activation of NF- ( p-Coumaric acid is largely present in grapes, oranges, apples, tomatoes, spinach, and potatoes

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