If switching from tirzepatide to retatrutide, start retatrutide at 2 mg regardless of your previous tirzepatide dose and titrate up on the standard schedule
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Individuals with insulin resistance, prediabetes, or type 2 diabetes may see additional metabolic benefits beyond weight loss, including improved glycemic control
Tapering can help your body slowly readjust to its natural appetite and hunger signals, potentially making the transition smoother and reducing the shock of a sudden increase in hunger
Your healthcare team can provide personalised advice based on your individual circumstances, ensuring that any decision to stop GLP-1 therapy is safe, well-planned, and supported by appropriate monitoring and alternative management strategies where needed
Individual variation in GLP-1 receptor sensitivity means that some people will be extremely sensitive to even small changes in drug concentration while others barely notice the difference between peak and trough
