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Other recognised contributors to RLS include chronic kidney disease (particularly uraemia), pregnancy, and certain medications such as some antidepressants (SSRIs/SNRIs), antipsychotics, and dopamine antagonists (including anti-nausea medications like metoclopramide)

Many Lt strains can degrade malate but some of them are also able to produce small amounts of malic acid, up to 0.3 g/L (Hranilovic et al., 2018)