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A clinical study involving 564 adults (BMI 30-40 kg/m2, without T2DM) found that compared with orlistat (3120 mg, weight loss of 4.1 kg), LIR (subcutaneous administration of 1.2 mg/d, 1.8 mg/d, 2.4 mg/d or 3 mg/d) had an average weight loss of 4.8-7.2 kg, the two-year extended experiment of which also showed similar results (88, 89)

SDSST, standard dose Synacthen stimulation test

The pancreas was then dissected, incubated at 37 C for 10 minutes, and digestion halted with cold RPMI-1640 supplemented with 10% FBS (F7524, SigmaAldrich) and 1% (v/v) penicillin/streptomycin solution (15070-063, Invitrogen)

Infection: Treat per guidelines