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Continued over-stimulation of pancreatic -cells by whey protein-driven IIS after the post-weaning period may continuously diminish nuclear FoxO levels, thereby promoting oxidative stress damage of -cells finally resulting in early onset of -cell cellular senescence and apoptosis [26]

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Park S, Lim W, Bazer FW, Song G (2018) Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells

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