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That sequence left Canada open to generic competition far earlier than other major markets
The data examined in this report show that most commercial patients face significant hurdles: large denial rates (often two-thirds of requests), multi-day delays (median ~6 days if not instant-approve), and high first-fill abandonment (fill rates commonly 60%)
The negotiations that followed demonstrated just how difficult it remains to reconcile commercial interests with public health priorities
Addressing the Wear-Off Effect Others notice that their appetite begins to return on day six or seven of their weekly cycle
Tirzepatides dual-hormone action means some patients experience these effects slightly more often, though this varies significantly from person to person
