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Compared to GLP-1 receptor agonist monotherapy, which requires frequent dosing and may lead to receptor desensitization, gene delivery using plasmids or siRNA, such as polyethyleneimine (PEI)-based complexes encoding GLP-1 or LNPs designed to silence GCGR expression, enables endogenous regulation of hormonal homeostasis

McEwen BS, Nasca C, Gray JD

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On the other hand, overexpression of HO-1 can lead to excessive free iron release, promoting Fenton reactions and potentially exacerbating ferroptosis under specific conditions (128)

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