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On top of its important role as the powerhouse of the cell, these organelles are also essential regulators of cellular metabolism, redox state, intracellular calcium signaling, and programmed cell death mechanisms [12,13,14,15]

Pesci A, Balbi B, Majori M, et al

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This is not a set-it-and-forget-it transition it requires close monitoring and ideally a care team experienced in adjusting insulin regimens