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For example, hydroxocobalamin (a form of B12) is retained in the liver and blood longer than other forms, so it is often given every 2 to 3 months [7] [2]

Tolerance development : Effects diminish over time, requiring higher doses

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Oral and parenteral magnesium supplements were relatively ineffective at correcting the problem, but stopping PPI therapy lead to prompt resolution of the hypomagnesemia (within 2 weeks in five carefully monitored patients), with symptomatic benefit

However, it is not FDA-approved for medical treatment or injection, and regulatory status may vary by use