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where E m represents the maximal stimulation of the system, K A is the agonistreceptor dissociation constant, in molar concentration, [ A ] is the molar concentration of ligand and is the operational measure of efficacy in the system, which incorporates signalling efficacy and receptor density

Biomed Pharmacol J 2022;15:18818

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KLOW is commonly seen as a blend containing those same three components plus KPV, giving it a broader four-component profile